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Ozone & Platelet Rich Fibrin (PRF) Can Mean Better Results with Dental Implants

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About three years ago, we told you about some of the research supporting two important tools we use when placing ceramic dental implants: ozone and platelet rich fibrin (PRF). Science was already showing that these adjunct therapies support good healing and better integration of the implants with jaw bone.

Since then, the evidence base for ozone and PRF in implant dentistry has only grown stronger. And together? They provide good insurance for an optimal, long-lasting result for your investment in biocompatible implants.

New Evidence for Ozone in Biological Implant Dentistry

Just last year, a new review of the science appeared in Quintessence International. Its authors began by searching three large databases of medical research for potentially relevant studies. Seven of those involving 225 patients met all of the authors’ criteria. Only controlled trials were considered – that is, studies in which one group of patients got ozone while another got an alternative adjunct treatment or placebo.

Ozone therapy had a positive effect on outcomes directly or indirectly related to periodontal/peri-implant surgical wound healing. Furthermore, it could also increase the stability of immediately loaded single implants installed in the posterior mandible.

Greater stability, in addition to decreased bone loss, was confirmed more recently in an Egyptian study of 18 patients who underwent implant surgery with bone grafts. Half of those patients received the usual grafting material while the others received ozone gel in addition to the grafting material.

After 9 months, those who received ozone had more stable implants and less bone loss than those who did not.

More recently, a case study documented that not only was there better healing after implant surgery with ozone; healing was faster, too,

characterized by the absence of pain and subsidence of swelling within a week, facilitating an expedited resumption of regular dietary practices. The outcomes of this case underscore the potential role of Ozone Therapy in augmenting postoperative recovery, primarily through its antimicrobial attributes and the facilitation of enhanced tissue oxygenation.

New Evidence for Platelet Rich Fibrin (PRF) in Biological Implant Dentistry

A recent review suggests that platelet rich fibrin may help improve implant stability, too. In this case, the research team scoured five major medical databases for studies on the matter. Only randomized controlled trials involving at least 10 patients were included.

Analysis of the 10 studies that made the cut “showed that PRF increased the effect of
implant stabilizers after implant surgery.” The authors also noted that

PRF may also have a role in accelerating bone healing and tends to promote new bone formation at the implant site.

This, in fact, was shown by a study published last year in Cureus, in which 20 patients underwent implant surgery. Half received PRF, half did not. CBCT scans were used to evaluate the amount of alveolar bone before surgery. (Alveolar bone is the part of the jawbone that holds the tooth sockets). Various oral health measures were also taken, along with changes in the bone surrounding the implant. Patients were evaluated during placement, as well as 6 and 9 months after surgery.

The researchers found that the PRF group had significantly better pocket depth and gum scores compared to the control group at all checkpoints. X-ray assessments showed that they experienced less bone loss than the control group at all checkpoints.

The provided data demonstrated that the local injection of PRF during implant placement has the potential to favorably stimulate bone formation, and may be used as a therapeutic adjuvant in the clinical setting of implant placement.

As important as all these findings are, though, the most important thing – to us, anyway – is the happiness of our patients with the long term success of their ceramic dental implants. PRF and ozone are just two of the tools that make that happen.

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